Structure‐based non‐nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit reverse transcription and block the replication of HIV‐1. Currently, NNRTIs are usually used as part of a three‐drug combination given to patients as antiretroviral therapy. These combinations involve other classes of anti‐HIV‐1 drugs,...

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Bibliographic Details
Published in:Chem Biol Drug Des
Main Authors: Smith, Steven J., Pauly, Gary T., Hewlett, Katharine, Schneider, Joel P., Hughes, Stephen H.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821153/
https://ncbi.nlm.nih.gov/pubmed/32743937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13766
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