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Targeting Telomeres: Molecular Dynamics and Free Energy Simulation of Gold-Carbene Binding to DNA
DNA sequences in regulatory regions and in telomers at the ends of chromosomes frequently contain tandem repeats of guanine nucleotides that can form stacked structures stabilized by Hoogsten pairing and centrally bound monovalent cations. The replication and elongation of telomeres requires the dis...
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| Published in: | Biophys J |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7820797/ https://ncbi.nlm.nih.gov/pubmed/33285115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.11.2263 |
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