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Targeting Telomeres: Molecular Dynamics and Free Energy Simulation of Gold-Carbene Binding to DNA

DNA sequences in regulatory regions and in telomers at the ends of chromosomes frequently contain tandem repeats of guanine nucleotides that can form stacked structures stabilized by Hoogsten pairing and centrally bound monovalent cations. The replication and elongation of telomeres requires the dis...

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Pubblicato in:Biophys J
Autori principali: Nayis, Asmar, Liebl, Korbinian, Frost, Christina V., Zacharias, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820797/
https://ncbi.nlm.nih.gov/pubmed/33285115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.11.2263
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