UFMylation inhibits the proinflammatory capacity of interferon-γ–activated macrophages

Macrophages activated with interferon-γ (IFN-γ) in combination with other proinflammatory stimuli, such as lipopolysaccharide or tumor necrosis factor-α (TNF-α), respond with transcriptional and cellular changes that enhance clearance of intracellular pathogens at the risk of damaging tissues. IFN-γ...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Balce, Dale R., Wang, Ya-Ting, McAllaster, Michael R., Dunlap, Bria F., Orvedahl, Anthony, Hykes, Barry L., Droit, Lindsay, Handley, Scott A., Wilen, Craig B., Doench, John G., Orchard, Robert C., Stallings, Christina L., Virgin, Herbert W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817147/
https://ncbi.nlm.nih.gov/pubmed/33372156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011763118
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