Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Host inflammatory responses must be tightly regulated to ensure effective immunity while limiting tissue injury. IFN gamma (IFNγ) primes macrophages to mount robust inflammatory responses. However, IFNγ also induces cell death, and the pathways that regulate IFNγ-induced cell death are incompletely...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Orvedahl, Anthony, McAllaster, Michael R., Sansone, Amy, Dunlap, Bria F., Desai, Chandni, Wang, Ya-Ting, Balce, Dale R., Luke, Cliff J., Lee, Sanghyun, Orchard, Robert C., Artyomov, Maxim N., Handley, Scott A., Doench, John G., Silverman, Gary A., Virgin, Herbert W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697821/
https://ncbi.nlm.nih.gov/pubmed/31346084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1822157116
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