Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster class of drugs nitrogen-containing bisphosphonates represent one of the best-known examples. Widely used to treat bone-resorptio...

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Bibliographic Details
Published in:Front Chem
Main Authors: Park, Jaeok, Pandya, Vishal R., Ezekiel, Sean J., Berghuis, Albert M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815940/
https://ncbi.nlm.nih.gov/pubmed/33490038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.612728
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