טוען...
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β
Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor–β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between thrombin catalytic activity and release of mature T...
שמור ב:
| הוצא לאור ב: | Sci Transl Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7814995/ https://ncbi.nlm.nih.gov/pubmed/31915300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay4860 |
| תגים: |
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