GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon

Activated regulatory T (T(reg)) cells express the surface receptor glycoprotein-A repetitions predominant (GARP), which binds and activates latent transforming growth factor-beta (TGF-β). How GARP modulates T(reg) function in inflammation and cancer remains unclear. Here we demonstrate that loss of...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Salem, Mohammad, Wallace, Caroline, Velegraki, Maria, Li, Anqi, Ansa-Addo, Ephraim, Metelli, Alessandra, Kwon, Hyunwoo, Riesenberg, Brian, Wu, Bill, Zhang, Yongliang, Guglietta, Silvia, Sun, Shaoli, Liu, Bei, Li, Zihai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420855/
https://ncbi.nlm.nih.gov/pubmed/30674536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2623
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