Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor–β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between thrombin catalytic activity and release of mature T...

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Publicat a:Sci Transl Med
Autors principals: Metelli, Alessandra, Wu, Bill X., Riesenberg, Brian, Guglietta, Silvia, Huck, John D., Mills, Catherine, Li, Anqi, Rachidi, Saleh, Krieg, Carsten, Rubinstein, Mark P., Gewirth, Daniel T., Sun, Shaoli, Lilly, Michael B., Wahlquist, Amy H., Carbone, David P., Yang, Yiping, Liu, Bei, Li, Zihai
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814995/
https://ncbi.nlm.nih.gov/pubmed/31915300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay4860
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