Platelets Subvert T Cell Immunity Against Cancer via GARP-TGFβ Axis

Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy and resistance to therapy by dampening host immunity. We herein show that genetic targeting of platelets significantly enhances...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Rachidi, Saleh, Metelli, Alessandra, Riesenberg, Brian, Wu, Bill X, Nelson, Michelle H, Fugle, Caroline W, Paulos, Chrystal M, Rubinstein, Mark P, Garrett-Mayer, Elizabeth, Hennig, Mirko, Bearden, Daniel W, Yang, Yi, Liu, Bei, Li, Zihai
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539882/
https://ncbi.nlm.nih.gov/pubmed/28763790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aai7911
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