Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Astrocytes are highly specialised cells, responsible for CNS homeostasis and neuronal activity. Lack of human in vitro systems able to recapitulate the functional changes affecting astrocytes during ageing represents a major limitation to studying mechanisms and potential therapies aiming to preserv...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811849/
https://ncbi.nlm.nih.gov/pubmed/33314575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13281
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