Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome

Adeno-associated viruses (AAVs) are attractive gene therapy vectors due to their low toxicity, high stability, and rare integration into the host genome. Expressing ligands on the viral capsid can re-target AAVs to new cell types, but limited sites have been identified on the capsid that tolerate a...

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Publicado no:Sci Rep
Main Authors: Chandran, Jayanth S., Sharp, Paul S., Karyka, Evangelia, Aves-Cruzeiro, João Miguel da Conceição, Coldicott, Ian, Castelli, Lydia, Hautbergue, Guillaume, Collins, Mark O., Azzouz, Mimoun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676692/
https://ncbi.nlm.nih.gov/pubmed/29116194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15255-2
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