Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease. SMA is caused by mutations in the survival motor neuron gene (SMN1), leading to reduced levels of SMN protein in the CNS. The actin-binding protein plastin 3 (PLS3) has been reported as a modifier for SMA, making it a pot...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Alrafiah, Aziza, Karyka, Evangelia, Coldicott, Ian, Iremonger, Kayleigh, Lewis, Katherin E., Ning, Ke, Azzouz, Mimoun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852384/
https://ncbi.nlm.nih.gov/pubmed/29552580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.01.007
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