Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Astrocytes are highly specialised cells, responsible for CNS homeostasis and neuronal activity. Lack of human in vitro systems able to recapitulate the functional changes affecting astrocytes during ageing represents a major limitation to studying mechanisms and potential therapies aiming to preserv...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Aging Cell
Autori principali: Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811849/
https://ncbi.nlm.nih.gov/pubmed/33314575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13281
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