Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

BACKGROUND: Astrocytes regulate neuronal function, synaptic formation and maintenance partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) astrocytes display a toxic phenotype that contributes to motor neuron (MN) degeneration. METHODS: We used human induced a...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413467/
https://ncbi.nlm.nih.gov/pubmed/30711519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.067
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