Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pathology with therapeutic relevance, but developing...

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Pubblicato in:Mol Metab
Autori principali: Hardee, Justin P., Martins, Karen J.B., Miotto, Paula M., Ryall, James G., Gehrig, Stefan M., Reljic, Boris, Naim, Timur, Chung, Jin D., Trieu, Jen, Swiderski, Kristy, Philp, Ashleigh M., Philp, Andrew, Watt, Matthew J., Stroud, David A., Koopman, Rene, Steinberg, Gregory R., Lynch, Gordon S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811171/
https://ncbi.nlm.nih.gov/pubmed/33359740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101157
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