17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple orthogonal validation approaches, we identified g...

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Publicat a:iScience
Autors principals: Singh, Shivendra, Abu-Zaid, Ahmed, Lin, Wenwei, Low, Jonathan, Abdolvahabi, Alireza, Jin, Hongjian, Wu, Qiong, Cooke, Bailey, Fang, Jie, Bowling, John, Vaithiyalingam, Sivaraja, Currier, Duane, Yun, Mi-Kyung, Fernando, Dinesh M., Maier, Julie, Tillman, Heather, Bulsara, Purva, Lu, Zhaohua, Das, Sourav, Shelat, Anang, Li, Zhenmei, Young, Brandon, Lee, Richard, Rankovic, Zoran, Murphy, Andrew J., White, Stephen W., Davidoff, Andrew M., Chen, Taosheng, Yang, Jun
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811140/
https://ncbi.nlm.nih.gov/pubmed/33490904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101996
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