17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple orthogonal validation approaches, we identified g...

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發表在:iScience
Main Authors: Singh, Shivendra, Abu-Zaid, Ahmed, Lin, Wenwei, Low, Jonathan, Abdolvahabi, Alireza, Jin, Hongjian, Wu, Qiong, Cooke, Bailey, Fang, Jie, Bowling, John, Vaithiyalingam, Sivaraja, Currier, Duane, Yun, Mi-Kyung, Fernando, Dinesh M., Maier, Julie, Tillman, Heather, Bulsara, Purva, Lu, Zhaohua, Das, Sourav, Shelat, Anang, Li, Zhenmei, Young, Brandon, Lee, Richard, Rankovic, Zoran, Murphy, Andrew J., White, Stephen W., Davidoff, Andrew M., Chen, Taosheng, Yang, Jun
格式: Artigo
語言:Inglês
出版: Elsevier 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811140/
https://ncbi.nlm.nih.gov/pubmed/33490904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101996
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