Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis

Phenotypic screening through high-content automated microscopy is a powerful tool for evaluating the mechanism of action of candidate therapeutics. Despite more than a decade of development, however, high content assays have yielded mixed results, identifying robust phenotypes in only a small subset...

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Udgivet i:PLoS One
Main Authors: Twarog, Nathaniel R., Low, Jonathan A., Currier, Duane G., Miller, Greg, Chen, Taosheng, Shelat, Anang A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757101/
https://ncbi.nlm.nih.gov/pubmed/26886014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149439
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