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A High Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors
Class O forkhead box (FOXO) transcription factors are downstream targets of the PI3K/AKT signaling pathway, which is upregulated in many tumors. AKT phosphorylates and inactivates FOXO1 by relocating it to the cytoplasm. Because FOXO1 functions as a tumor suppressor by negatively regulating cell-cyc...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536487/ https://ncbi.nlm.nih.gov/pubmed/21471460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110397889 |
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