A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

[Image: see text] Pantothenate kinase (PanK) is a regulatory enzyme that controls coenzyme A (CoA) biosynthesis. The association of PanK with neurodegeneration and diabetes suggests that chemical modifiers of PanK activity may be useful therapeutics. We performed a high throughput screen of >5200...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Sharma, Lalit Kumar, Leonardi, Roberta, Lin, Wenwei, Boyd, Vincent A., Goktug, Asli, Shelat, Anang A., Chen, Taosheng, Jackowski, Suzanne, Rock, Charles O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357395/
https://ncbi.nlm.nih.gov/pubmed/25569308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501585q
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