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Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
The human isoform 2 of pantothenate kinase (PanK2) is localized to the mitochondria, and mutations in this protein are associated with a progressive neurodegenerative disorder. PanK2 inhibition by acetyl-CoA is so stringent (IC(50) < 1 μM) that it is unclear how the enzyme functions in the presen...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1785270/ https://ncbi.nlm.nih.gov/pubmed/17242360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607621104 |
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