17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma

Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple orthogonal validation approaches, we identified g...

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Publicado no:iScience
Main Authors: Singh, Shivendra, Abu-Zaid, Ahmed, Lin, Wenwei, Low, Jonathan, Abdolvahabi, Alireza, Jin, Hongjian, Wu, Qiong, Cooke, Bailey, Fang, Jie, Bowling, John, Vaithiyalingam, Sivaraja, Currier, Duane, Yun, Mi-Kyung, Fernando, Dinesh M., Maier, Julie, Tillman, Heather, Bulsara, Purva, Lu, Zhaohua, Das, Sourav, Shelat, Anang, Li, Zhenmei, Young, Brandon, Lee, Richard, Rankovic, Zoran, Murphy, Andrew J., White, Stephen W., Davidoff, Andrew M., Chen, Taosheng, Yang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811140/
https://ncbi.nlm.nih.gov/pubmed/33490904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101996
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