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Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes

Chimeric antigen receptor (CAR) T cell therapy has shown considerable promise for hematologic malignancies, leading to the US Food and Drug Administration approval of two CAR T cell–based therapies for the treatment of B cell acute lymphoblastic leukemia and large B cell lymphoma. Despite success in...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Roselli, Emiliano, Faramand, Rawan, Davila, Marco L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810492/
https://ncbi.nlm.nih.gov/pubmed/33463538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI142030
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