ODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing

BACKGROUND: Dolutegravir (DTG)-based antiretroviral therapy (ART) is highly effective and well-tolerated in adults and is rapidly being adopted globally. We describe the design of the ODYSSEY trial which evaluates the efficacy and safety of DTG-based ART compared with standard-of-care in children an...

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Gepubliceerd in:BMC Infect Dis
Hoofdauteurs: Moore, Cecilia L., Turkova, Anna, Mujuru, Hilda, Kekitiinwa, Adeodata, Lugemwa, Abbas, Kityo, Cissy M., Barlow-Mosha, Linda N., Cressey, Tim R., Violari, Avy, Variava, Ebrahim, Cotton, Mark F., Archary, Moherndran, Compagnucci, Alexandra, Puthanakit, Thanyawee, Behuhuma, Osee, Saϊdi, Yacine, Hakim, James, Amuge, Pauline, Atwine, Lorna, Musiime, Victor, Burger, David M., Shakeshaft, Clare, Giaquinto, Carlo, Rojo, Pablo, Gibb, Diana M., Ford, Deborah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809782/
https://ncbi.nlm.nih.gov/pubmed/33446115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-020-05672-6
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