ODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing

BACKGROUND: Dolutegravir (DTG)-based antiretroviral therapy (ART) is highly effective and well-tolerated in adults and is rapidly being adopted globally. We describe the design of the ODYSSEY trial which evaluates the efficacy and safety of DTG-based ART compared with standard-of-care in children an...

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Pubblicato in:BMC Infect Dis
Autori principali: Moore, Cecilia L., Turkova, Anna, Mujuru, Hilda, Kekitiinwa, Adeodata, Lugemwa, Abbas, Kityo, Cissy M., Barlow-Mosha, Linda N., Cressey, Tim R., Violari, Avy, Variava, Ebrahim, Cotton, Mark F., Archary, Moherndran, Compagnucci, Alexandra, Puthanakit, Thanyawee, Behuhuma, Osee, Saϊdi, Yacine, Hakim, James, Amuge, Pauline, Atwine, Lorna, Musiime, Victor, Burger, David M., Shakeshaft, Clare, Giaquinto, Carlo, Rojo, Pablo, Gibb, Diana M., Ford, Deborah
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809782/
https://ncbi.nlm.nih.gov/pubmed/33446115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-020-05672-6
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