Influence of age and co-medication on dolutegravir glucuronidation in paediatric patients

Dolutegravir (DTG) is primarily metabolized by uridine diphosphate glucuronosyl-transferases, forming the pharmacologically inactive DTG glucuronide (DTG-gluc). We described the dolutegravir metabolic ratio (DTG-MR; DTG-gluc AUC(0−24h) divided by DTG AUC(0−24h)) in 85 children with HIV aged 3 months...

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Udgivet i:Br J Clin Pharmacol
Main Authors: Jacobs, Tom G., Waalewijn, Hylke, Houlden, Lily, Bollen, Pauline D.J., Nanduudu, Annet, Nambi, Esether, Cassim, Haseena, Lugemwa, Abbas, Makumbi, Shafic, Monkiewicz, Lara N., Shakeshaft, Clare, Bamford, Alasdair, Archary, Moherndran, Musuro, Godfrey, Chidziva, Ennie, Mujuru, Hilda A., Bwakura-Dangarembizi, Mutsa, Chabala, Chishala, Turkova, Anna, Gibb, Di M., Cotton, Mark F., Aarnoutse, Rob, Burger, David M., Colbers, Angela
Format: Artigo
Sprog:Inglês
Udgivet: 2024
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616883/
https://ncbi.nlm.nih.gov/pubmed/39228168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.16238
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