Influence of age and co-medication on dolutegravir glucuronidation in paediatric patients

Dolutegravir (DTG) is primarily metabolized by uridine diphosphate glucuronosyl-transferases, forming the pharmacologically inactive DTG glucuronide (DTG-gluc). We described the dolutegravir metabolic ratio (DTG-MR; DTG-gluc AUC(0−24h) divided by DTG AUC(0−24h)) in 85 children with HIV aged 3 months...

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Publicado no:Br J Clin Pharmacol
Main Authors: Jacobs, Tom G., Waalewijn, Hylke, Houlden, Lily, Bollen, Pauline D.J., Nanduudu, Annet, Nambi, Esether, Cassim, Haseena, Lugemwa, Abbas, Makumbi, Shafic, Monkiewicz, Lara N., Shakeshaft, Clare, Bamford, Alasdair, Archary, Moherndran, Musuro, Godfrey, Chidziva, Ennie, Mujuru, Hilda A., Bwakura-Dangarembizi, Mutsa, Chabala, Chishala, Turkova, Anna, Gibb, Di M., Cotton, Mark F., Aarnoutse, Rob, Burger, David M., Colbers, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616883/
https://ncbi.nlm.nih.gov/pubmed/39228168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.16238
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