Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients

Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch signaling may synergistically promote the expression of the intestinal stem cell (ISC)...

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Publicado no:Biochem Biophys Rep
Main Authors: Kuno, Reiko, Ito, Go, Kawamoto, Ami, Hiraguri, Yui, Sugihara, Hady Yuki, Takeoka, Sayaka, Nagata, Sayaka, Takahashi, Junichi, Tsuchiya, Mao, Anzai, Sho, Mizutani, Tomohiro, Shimizu, Hiromichi, Yui, Shiro, Oshima, Shigeru, Tsuchiya, Kiichiro, Watanabe, Mamoru, Okamoto, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808948/
https://ncbi.nlm.nih.gov/pubmed/33490652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100906
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