Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients

Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch signaling may synergistically promote the expression of the intestinal stem cell (ISC)...

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Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Kuno, Reiko, Ito, Go, Kawamoto, Ami, Hiraguri, Yui, Sugihara, Hady Yuki, Takeoka, Sayaka, Nagata, Sayaka, Takahashi, Junichi, Tsuchiya, Mao, Anzai, Sho, Mizutani, Tomohiro, Shimizu, Hiromichi, Yui, Shiro, Oshima, Shigeru, Tsuchiya, Kiichiro, Watanabe, Mamoru, Okamoto, Ryuichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808948/
https://ncbi.nlm.nih.gov/pubmed/33490652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2020.100906
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