Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

BACKGROUND: Intestinal stem cells (ISCs) play indispensable roles in the maintenance of homeostasis, and also in the regeneration of the damaged intestinal epithelia. However, whether the inflammatory environment of Crohn’s disease (CD) affects properties of resident small intestinal stem cells rema...

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Publicado en:J Gastroenterol
Autores principales: Suzuki, Kohei, Murano, Tatsuro, Shimizu, Hiromichi, Ito, Go, Nakata, Toru, Fujii, Satoru, Ishibashi, Fumiaki, Kawamoto, Ami, Anzai, Sho, Kuno, Reiko, Kuwabara, Konomi, Takahashi, Junichi, Hama, Minami, Nagata, Sayaka, Hiraguri, Yui, Takenaka, Kento, Yui, Shiro, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Japan 2018
Materias:
Original Article—Alimentary Tract
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132922/
https://ncbi.nlm.nih.gov/pubmed/29374777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-018-1437-3
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