Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

BACKGROUND: Intestinal stem cells (ISCs) play indispensable roles in the maintenance of homeostasis, and also in the regeneration of the damaged intestinal epithelia. However, whether the inflammatory environment of Crohn’s disease (CD) affects properties of resident small intestinal stem cells rema...

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Bibliografiske detaljer
Udgivet i:J Gastroenterol
Main Authors: Suzuki, Kohei, Murano, Tatsuro, Shimizu, Hiromichi, Ito, Go, Nakata, Toru, Fujii, Satoru, Ishibashi, Fumiaki, Kawamoto, Ami, Anzai, Sho, Kuno, Reiko, Kuwabara, Konomi, Takahashi, Junichi, Hama, Minami, Nagata, Sayaka, Hiraguri, Yui, Takenaka, Kento, Yui, Shiro, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi
Format: Artigo
Sprog:Inglês
Udgivet: Springer Japan 2018
Fag:
Original Article—Alimentary Tract
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132922/
https://ncbi.nlm.nih.gov/pubmed/29374777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-018-1437-3
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