Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

BACKGROUND: Intestinal stem cells (ISCs) play indispensable roles in the maintenance of homeostasis, and also in the regeneration of the damaged intestinal epithelia. However, whether the inflammatory environment of Crohn’s disease (CD) affects properties of resident small intestinal stem cells rema...

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Detalhes bibliográficos
Publicado no:J Gastroenterol
Main Authors: Suzuki, Kohei, Murano, Tatsuro, Shimizu, Hiromichi, Ito, Go, Nakata, Toru, Fujii, Satoru, Ishibashi, Fumiaki, Kawamoto, Ami, Anzai, Sho, Kuno, Reiko, Kuwabara, Konomi, Takahashi, Junichi, Hama, Minami, Nagata, Sayaka, Hiraguri, Yui, Takenaka, Kento, Yui, Shiro, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2018
Assuntos:
Original Article—Alimentary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132922/
https://ncbi.nlm.nih.gov/pubmed/29374777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-018-1437-3
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