Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3

Overexpression of D-type cyclins in human cancer frequently occurs as a result of protein stabilization, emphasizing the importance of identification of the machinery that regulates their ubiqutin-dependent degradation. Cyclin D3 is overexpressed in ~50% of Burkitt’s lymphoma correlating with a muta...

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Bibliographic Details
Published in:Oncogene
Main Authors: Yoshida, Akihiro, Choi, Jaewoo, Jin, Hong Ri, Li, Yan, Bajpai, Sagar, Qie, Shuo, Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808939/
https://ncbi.nlm.nih.gov/pubmed/33122824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01532-4
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