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Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3
Overexpression of D-type cyclins in human cancer frequently occurs as a result of protein stabilization, emphasizing the importance of identification of the machinery that regulates their ubiqutin-dependent degradation. Cyclin D3 is overexpressed in ~50% of Burkitt’s lymphoma correlating with a muta...
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| Pubblicato in: | Oncogene |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7808939/ https://ncbi.nlm.nih.gov/pubmed/33122824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01532-4 |
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