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F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

Hematologic maligancies exhibit a growth advantage by up-regulation of components within the molecular apparatus involved in cell-cycle progression. The SCF (Skip-Cullin1-F-box protein) E3 ligase family provides homeostatic feedback control of cell division by mediating ubiquitination and degradatio...

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Bibliografiske detaljer
Main Authors: Chen, Bill B., Glasser, Jennifer R., Coon, Tiffany A., Zou, Chunbin, Miller, Hannah L., Fenton, Moon, McDyer, John F., Boyiadzis, Michael, Mallampalli, Rama K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321873/
https://ncbi.nlm.nih.gov/pubmed/22323446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-358911
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