F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation

The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system–related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an ‘orphan’ member of the Skp1–Cul...

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Hauptverfasser: Zhao, Jing, Wei, Jianxin, Mialki, Rachel K, Mallampalli, Daniel F, Chen, Bill B, Coon, Tiffany, Zou, Chunbin, Mallampalli, Rama K, Zhao, Yutong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643313/
https://ncbi.nlm.nih.gov/pubmed/22660580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2341
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