Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations

Nine compounds (MO1–MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC(50) value of 0.030 µM, followed by MO7 (0....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Enzyme Inhib Med Chem
Egile Nagusiak: Sasidharan, Rani, Eom, Bo Hyun, Heo, Jeong Hyun, Park, Jong Eun, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Manju, Sreedharannair Leelabaiamma, Mathew, Bijo, Kim, Hoon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2021
Gaiak:
Short Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808749/
https://ncbi.nlm.nih.gov/pubmed/33430657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1842390
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