Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors

Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty-two of the 24 COEs synthesized, except COE-17 and COE-24, had potent and/or significant selective inhibitory effects on MAO-B....

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Veröffentlicht in:Molecules
Hauptverfasser: Oh, Jong Min, Rangarajan, T. M., Chaudhary, Reeta, Singh, Rishi Pal, Singh, Manjula, Singh, Raj Pal, Tondo, Anna Rita, Gambacorta, Nicola, Nicolotti, Orazio, Mathew, Bijo, Kim, Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288026/
https://ncbi.nlm.nih.gov/pubmed/32443652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25102356
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