Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations

Nine compounds (MO1–MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC(50) value of 0.030 µM, followed by MO7 (0....

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Sasidharan, Rani, Eom, Bo Hyun, Heo, Jeong Hyun, Park, Jong Eun, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Manju, Sreedharannair Leelabaiamma, Mathew, Bijo, Kim, Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808749/
https://ncbi.nlm.nih.gov/pubmed/33430657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1842390
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