Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations

Nine compounds (MO1–MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC(50) value of 0.030 µM, followed by MO7 (0....

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Dades bibliogràfiques
Publicat a:J Enzyme Inhib Med Chem
Autors principals: Sasidharan, Rani, Eom, Bo Hyun, Heo, Jeong Hyun, Park, Jong Eun, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Manju, Sreedharannair Leelabaiamma, Mathew, Bijo, Kim, Hoon
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2021
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808749/
https://ncbi.nlm.nih.gov/pubmed/33430657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1842390
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