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Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...

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Bibliografiske detaljer
Udgivet i:Pharmaceutics
Main Authors: Koyiparambath, Vishal Payyalot, Oh, Jong Min, Khames, Ahmed, Abdelgawad, Mohamed A., Nair, Aathira Sujathan, Nath, Lekshmi R., Gambacorta, Nicola, Ciriaco, Fulvio, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226672/
https://ncbi.nlm.nih.gov/pubmed/34201128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060850
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