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Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...

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書誌詳細
出版年:Pharmaceutics
主要な著者: Koyiparambath, Vishal Payyalot, Oh, Jong Min, Khames, Ahmed, Abdelgawad, Mohamed A., Nair, Aathira Sujathan, Nath, Lekshmi R., Gambacorta, Nicola, Ciriaco, Fulvio, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226672/
https://ncbi.nlm.nih.gov/pubmed/34201128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060850
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