Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders

Eleven piperazine-containing 1,3-diphenylprop-2-en-1-one derivatives (PC1-PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs), cholinesterases (ChEs), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) with a view toward developing new treatments for n...

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Detalhes bibliográficos
Publicado no:Environ Sci Pollut Res Int
Main Authors: Mathew, Bijo, Oh, Jong Min, Baty, Roua S., Batiha, Gaber El-Saber, Parambi, Della Grace Thomas, Gambacorta, Nicola, Nicolotti, Orazio, Kim, Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980107/
https://ncbi.nlm.nih.gov/pubmed/33743158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11356-021-13320-y
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