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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

BACKGROUND: Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS: Using data from UK Biobank...

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מידע ביבליוגרפי
הוצא לאור ב:PLoS Med
Main Authors: Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2021
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808664/
https://ncbi.nlm.nih.gov/pubmed/33444330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003498
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