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A flexible and parallelizable approach to genome‐wide polygenic risk scores

The heritability of most complex traits is driven by variants throughout the genome. Consequently, polygenic risk scores, which combine information on multiple variants genome‐wide, have demonstrated improved accuracy in genetic risk prediction. We present a new two‐step approach to constructing gen...

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Veröffentlicht in:Genet Epidemiol
Hauptverfasser: Newcombe, Paul J., Nelson, Christopher P., Samani, Nilesh J., Dudbridge, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764842/
https://ncbi.nlm.nih.gov/pubmed/31328830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22245
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