Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

BACKGROUND: Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS: Using data from UK Biobank...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808664/
https://ncbi.nlm.nih.gov/pubmed/33444330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003498
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