Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample siz...

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Detalhes bibliográficos
Publicado no:J Am Coll Cardiol
Main Authors: Inouye, Michael, Abraham, Gad, Nelson, Christopher P., Wood, Angela M., Sweeting, Michael J., Dudbridge, Frank, Lai, Florence Y., Kaptoge, Stephen, Brozynska, Marta, Wang, Tingting, Ye, Shu, Webb, Thomas R., Rutter, Martin K., Tzoulaki, Ioanna, Patel, Riyaz S., Loos, Ruth J.F., Keavney, Bernard, Hemingway, Harry, Thompson, John, Watkins, Hugh, Deloukas, Panos, Di Angelantonio, Emanuele, Butterworth, Adam S., Danesh, John, Samani, Nilesh J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Biomedical 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176870/
https://ncbi.nlm.nih.gov/pubmed/30309464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2018.07.079
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