Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample siz...

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Publicat a:J Am Coll Cardiol
Autors principals: Inouye, Michael, Abraham, Gad, Nelson, Christopher P., Wood, Angela M., Sweeting, Michael J., Dudbridge, Frank, Lai, Florence Y., Kaptoge, Stephen, Brozynska, Marta, Wang, Tingting, Ye, Shu, Webb, Thomas R., Rutter, Martin K., Tzoulaki, Ioanna, Patel, Riyaz S., Loos, Ruth J.F., Keavney, Bernard, Hemingway, Harry, Thompson, John, Watkins, Hugh, Deloukas, Panos, Di Angelantonio, Emanuele, Butterworth, Adam S., Danesh, John, Samani, Nilesh J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Biomedical 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176870/
https://ncbi.nlm.nih.gov/pubmed/30309464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2018.07.079
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