Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

BACKGROUND: Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS: Using data from UK Biobank...

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Dettagli Bibliografici
Pubblicato in:PLoS Med
Autori principali: Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808664/
https://ncbi.nlm.nih.gov/pubmed/33444330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003498
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