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Kindlin-3 recruitment to the plasma membrane precedes high-affinity β(2)-integrin and neutrophil arrest from rolling
Integrin-mediated neutrophil adhesion starts by arrest from rolling. Activation of integrins involves conformational changes from an inactive, bent conformation to an extended conformation (E(+)) with high affinity for ligand binding (H(+)). The cytoplasmic protein kindlin-3 is necessary for leukocy...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7808012/ https://ncbi.nlm.nih.gov/pubmed/32777822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003446 |
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